MaTHiSiS provides an anthropocentric platform, which would focus on the needs, context and capacities of learners and subsequently adapt the learning process in a manner that maximizes learners’ engagement. The effectiveness of the learning experience, has been reached through the MaTHiSiS platform’s interconnected affect recognition, performance estimation and goal-based personalization & dynamic adaptation mechanisms. Moreover, the refined learning experience authoring tools and the robust learning analytics mechanism and interface provided by MaTHiSiS profoundly facilitate teachers, tutors and caregivers to understand their learners better and adjust their learning process more effectually and prolifically. Lastly, MaTHiSiS’ ubiquitous and transductive solutions for deploying learning experiences, with special attention to data security and privacy safeguarding, renders MaTHiSiS a powerful learning tool, able to adapt to a variety of learning contexts (formal, informal, non-formal education) and environments, learner types (from children to adults and from neurotypical to special abilities learners) and digital learning mediators (mobile, desktop, robot).