Go Back
Description
Offer Details
Photos
Location and Map
Contact
Related
Add to favorites:
Share:
β-Lactam inhibitors of viral proteases

Listing Description

Result description

We have developed β-lactam peptidomimetic inhibitors of flaviviral proteases with a molecular weight between 340 and 500 that are active in a cellular assay in the single-digit micromolar range, combined with low cytotoxicity and low off-target interference. A key structural element of the compound class is the inclusion of a β-lactam moiety in the structural backbone.

The β-lactam ring facilitates a large variation of substituents as well as 3D organization of the pharmacophore. Therefore, we are confident that this strategy opens a route to inhibitors of other proteases, such as the SARS-CoV-2 protease or TMPRSS2 that are crucial for entry and replication of SARS-CoV-2.

Addressing target audiences and expressing needs

Our needs are
  • Grants and Subsidies
We specifically need / are looking for

We are looking for projects and investors who would be interested in supporting and investing in the development of the β-lactam inhibitors of various proteases. The main interest and focus at this time would be on the coronavirus proteases to address the current and potentially future threats by coronaviruses.

Target audiences
  • Public or private funding institutions
  • Research and Technology Organisations

R&D, Technology and Innovation aspects

Current stage description

We synthesize diversely substituted β-lactams in a stereoselective fashion. We further couple them to various moieties, making the β-lactam either a central or terminal motif of a compound. The compounds are tested in a biochemical and cellular model. We have at our disposal assays for the determination of the activity against viral proteases, including the flavivirus and coronavirus protease. 

Result submitted to Horizon Results Platform by RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Offer Details

Specifications and Deliverables:

Value Proposition:

β-Lactams have a combination of properties that are rarely encountered in medicinal chemistry (e.g. peptidomimetic warhead with non-planar orientation of substituents). At the same time, they are surprisingly underexplored, possibly due to complex synthesis and characterization. We propose to use our extensive experience in the field to develop β-lactam coronavirus protease inhibitors. 

Input Required from Customer:

Fields of Application:

Patent/Publication Number

Main Patent Claims:

Patent Family:

Photos

Video

Documents

No documents available.

Location and Map

Adress:

SEMINARSTRASSE 2
Heidelberg
Baden-Württemberg
69117
Germany

Get Directions

Contact the listings owner

Connect with the Listing Owner!

💬 Please log in now to send a direct message to the listing owner. Not a member yet? Sign up for free and start connecting today!

Related Offers

Unlock Related Offers!

🚀 Gain access to related technology solutions that match your specific needs and interests—carefully selected to support your innovation goals. These offers are exclusively available to our professional members, helping you identify relevant technologies faster and start the right conversations with potential partners.

Upgrade to Professional now and never miss an important opportunity again! Already a member? Log in here to explore your matches.

Related Knowledgeable Resources

Discover More with Professional: Related Knowledge Resources

🔒 You’re missing out on expert-curated knowledge specifically matched to this topic. As a professional member, you gain exclusive access to in-depth articles, guides, and insights that help you make smarter decisions, faster.

Whether you’re preparing a funding proposal, researching a new market, or just need reliable information—our professional knowledge matches save you hours of research and point you directly to what matters.

Upgrade to Professional now  and instantly unlock relevant knowledge tailored to your needs! Already a member? Log in here to view your personalized content.

Viewers

See Who’s Interested in Your Offers!

🎯 Curious about who’s viewing your listings? Unlock insights into your last 20 visitors and discover potential leads instantly! This exclusive feature is only available to our professional members—helping you track engagement, connect with the right audience, and maximize your opportunities.

Upgrade to Professional now to gain access! Already a member? Log in here.