Result description
Here, we analyze the biophysical properties of the SARS-CoV-2 S-glycoprotein binding, on model surfaces and on living cells, to ACE2 receptors using force–distance (FD) curve-based atomic force microscopy (FD-curve-based AFM). We extract the kinetics and thermodynamics of the interactions established in vitro, and compare the binding properties of both the S1 subunit and RBD. Next, we test short ACE2-derived peptides targeting the viral S glycoprotein as potent binding inhibitor peptides and observe a significant reduction in the binding properties.
Radical Innovation Breakthrough
Drug delivery, Molecular recognition.
Addressing target audiences and expressing needs
Our needs are
- We are sharing our knowledge
Target audiences
- Others/ No specific audience
- Academia/ Universities
- Private Investors
R&D, Technology and Innovation aspects
Current stage description
We are testing others peptides
Result submitted to Horizon Results Platform by UNIVERSITE CATHOLIQUE DE LOUVAIN